Nidus is an Infested warframe. He is able to wield the Infestation in order to destroy his enemies, allowing him to mutate and defy death itself.
Nidus’ passive is Adaptive Mutation. Nidus is able to use a unique resource called Mutation. This can acquired by using some of his abilities, as we’ll see later on, and is used to fuel and enhance some of them. Mutation can stack up to one hundred. You can see Nidus’ current level of Mutation above his abilities, in the form of a ring. When the ring is full, you gain one level of Mutation. When Nidus has at least fifteen Mutation stacks, he becomes Undying. Instead of dying, fifteen Mutation stacks will be consumed and Nidus becomes invincible for a short duration. Some of his health will also be restored. Besides the Mutation resource, Nidus has no shields and possesses passive health regeneration and bonus ability strength.
Nidus’ fourth ability is Ravenous. Nidus creates an area of Infestation around him for a period of time. While in this area, Nidus and his allies will regenerate health over time. Ravenous can be recast while active but only one instance can exist at a time. If cast inside the existing area, the duration is refreshed and it will remain there. Several maggots are also spawned inside this area. These maggots will seek out nearby enemies and latch onto them. While attached to an enemy, each maggot will continuously stun them and deal Toxin damage over time.
Maggots possess their own health and will draw enemy fire. Maggots will die when the ability expires, the enemy they are attached to dies or they die. They can also be killed if they are hit by Virulence and will be highlighted when Virulence’s ability button is held. When a maggot dies it will explode, dealing Blast damage to enemies around them. This damage is amplified depending on Nidus’ current level of Mutation. Enemies hit by the explosion will contribute to Nidus’ Mutation level. Maggots will continuously respawn while Ravenous is active. This ability costs Mutation instead of energy.
Ability Strength mods affect the damage of Virulence, the Ability Strength bonus and the percentage of damage transferred of Parasitic Link and the health regeneration of Ravenous and the explosion damage from its maggots. The damage of Virulence and of Ravenous’ maggot explosion will also be amplified by Nidus’ current Mutation level. Ability Range mods affect the length of Virulence, the grab radius of Larva, the link range of Parasitic Link and the maggot explosion radius of Ravenous. Ability Duration mods affect the duration of Larva, Parasitic Link and Ravenous.
So, all things considered, here are some builds you may want to try on your Nidus: